Moreover, GLP-1RA exendin-4 improves insulin resistance by directly inhibiting the activation of nuclear factor-kappa-B (NF-B) within the murine macrophage cell line RAW264.7 [88, 89]
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Furthermore, the increased risk for diabetic retinopathy seems to occur early in treatment and be transient, ranging from three months to three years after starting a GLP-1 receptor agonist, while the duration of improvement in retinopathy attributable to glycemic control ranges from about three years to more than five years
These were metabolic and cardiovascular outcomes
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