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The alteration of the BBB is often marked by a degradation or shrinkage of ECs, alteration of the tight junction proteins connecting cells and modified transport mechanisms which all together impact greatly the BBB permeability

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A hallmark of ferroptosis is iron-dependent lipid peroxidation, which could be inhibited by the key ferroptosis regulator Gpx4, free radical trapping antioxidants and ferroptosis-specific inhibitors 501

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