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In Arabidopsis, arGST loss-of-function mutations were additionally linked with an increased content of flavonols 19,45 , most probably due to a second oxidation of accumulating flavan-3,3,4-triol ( 4 ), which is catalysed by At LDOX in vitro 11,12,13

g , Uptake of [ 13 C 2 , 15 N]-GSH (5 mM) into mitochondria isolated from HEK-293T SLC25A39 knockout cells expressing SLC25A39 cDNA for 10 min in the presence or absence of DTT (100 mM)

However, these studies are mostly observational , meaning they can show an association, but they do not prove that the medicines directly caused the benefits

2.8 Echocardiography examination All of the animals underwent an echocardiography examination at the end of the 8 th week with an ultrahigh-frequency and high-resolution small animal ultrasonic imaging system (VEVO 2100, Visual Sonics)

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