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In addition, the application of exendin-4, a GLP-1RA in obese mice triggered by diet restores C1q/TNF-related protein 3 (CTRP3) expression in keratinocytes, thereby inhibiting STAT3 phosphorylation via lysosomal-associated membrane protein 1 (LAMP1) and alleviating the psoriatic symptoms induced by imiquimod treatment [204]

Protocol approach 3: comprehensive repair (thymosin alpha-1 plus BPC-157 plus TB-500) Goal: Immune rebalancing combined with aggressive tissue repair Components: Thymosin alpha-1: 1.6 mg subcutaneously twice per week BPC-157: 250 mcg subcutaneously twice daily near affected tissue TB-500 : 2-5 mg subcutaneously twice per week for loading, then weekly for maintenance Rationale: This three-peptide approach targets immune regulation (TA1), mucosal and tissue healing (BPC-157), and cellular migration plus repair (TB-500)

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18 raises the possibility that this group failed to observe beneficial effects with peptides lacking 9092 because their peptides were not capped on either terminus