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Safety signals of special interest, including pancreatitis, gallbladder events, neoplasms, and suicidal ideation, were adjudicated by blinded expert committees

Risks & Unknowns No human safety data: The entire human safety profile is uncharacterized

Injection Tips Subcutaneous only

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Blood 115(24):51025110 Shawber CJ et al (2007) Notch alters VEGF responsiveness in human and murine endothelial cells by direct regulation of VEGFR-3 expression

This overlap suggests that FOXO4s activation by oxidative stress and inflammation might follow similar mechanisms, pointing to a broader role of FOXO4 in stress and immune response contexts