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As expected, in contrast to Dpp4 hep/ , Dpp4 EC/ mice had no decrease in hepatic Dpp4 mRNA expression (Supplemental Figure 2H), and, consistent with previous reports (38), systemic fasting plasma DPP4 activity and DPP4 protein levels (Supplemental Figure 2, I and J) were significantly decreased in Dpp4 EC/ mice compared with controls

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Normally TCAC reactions produce 3 NADH and 1 FADH 2 , resulting in a 3:1 NADH to FADH 2 ratio (Figure 6a)