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Entrapment efficiency (EE%) was determined indirectly by centrifuging the nanodispersions at 18,000 rpm for 0.5 h (chitosan NPs) and 1 h (spanlastics vesicles) with a cooling centrifuge (Beckman, Fullerton, Canada) at 4 C
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Betteridge, D
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No tolerance development to the lipolytic effects was noted in these studies, suggesting that unlike beta-2 agonists (which rapidly desensitize their receptors), beta-3 receptor activation may not produce the same downregulation pattern
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