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Exp Biol Med (Maywood)
Retatrutide is a triple agonist at three existing receptors: GLP-1 (glucagon-like peptide-1 receptor), GIP (glucose-dependent insulinotropic polypeptide receptor), and glucagon receptor
Dietary excess regulates absorption and surface of gut epithelium through intestinal PPARalpha
The PIONEER clinical trial program showed participants taking oral semaglutide lost between 7% and 13% of their baseline body weight over 68 weeks, depending on dose level and study cohort
Each treatment was performed in triplicate
Trial registration: clinicaltrials.gov: NCT03071666
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