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Although not required, if inserted while lying on ones side, consider remaining in the supine position for 1-3 minutes following insertion

H 2 O 2 signaling leads to the release of Nrf2 from complexes with Kelch-like ECH-associated protein 1 (Keap1) and ubiquitin ligase Cullin 3 and into the nucleus, where it binds to antioxidant response elements (ARE) and activates the expression of its target gene GPX8, which in turn regulates the expression of ER calcium by regulating SERCA (Granatiero et al., 2019)

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Strategies to bypass or disrupt the BBB are being explored, such as nanotechnology [7, 8], to improve drug delivery to the brain tumor