Its primary role is to upregulate proteins like actin, which is critical for cell migration, proliferation, and differentiation
A6 : Intended for adults
In mice, DNA damage results in melanocyte stem cell depletion and failure to self-renew (Jo et al., 2018)
Food and Drug Administration approved it in 2021 for chronic weight management
History [edit] Descriptions of deficiency effects [edit] Between 1849 and 1887, Thomas Addison described a case of pernicious anemia, William Osler and William Gardner first described a case of neuropathy, Hayem described large red cells in the peripheral blood in this condition, which he called "giant blood corpuscles" (now called macrocytes), Paul Ehrlich identified megaloblasts in the bone marrow, and Ludwig Lichtheim described a case of myelopathy
This was paired with a tendency to shorter T max after the morning dose compared to the night dose, although it did not reach statistical significance ( p = 0.182)