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La Crosse, United States of America: University of WisconsinLa Crosse (2019)
Mitochondrial Support and Energy Metabolism Function: Glutathione plays a vital role in maintaining mitochondrial integrity by protecting these organelles from oxidative damage
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2.3 System Xc - : cystine uptake and biosynthesis of GSH and polysulfides The supply of cysteine, the rate-limiting precursor for GSH, is maintained by the cystine/glutamate antiporter system Xc - , composed of SLC7A11 (also known as xCT) and SLC3A2 [76]
ROS can either (i) promote protumorigenic signaling supporting the proliferation and survival of cancer cells or (ii) conversely promote antitumorigenic signaling and oxidative stress-induced cancer cell death (Reczek and Chandel 2017)
