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In summary, the majority of studies found partial weight regain after cessation of GLP-1RA therapy, with significant variation in magnitude and timing

205,206,207 Delving into the peptide cyclization unfolds diverse approaches, most commonly used including head-to-tail, backbone-to-side chain, and side chain-to-side chain

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Tirzepatide (Zepbound for weight loss, Mounjaro for diabetes) achieved 22.5% average weight loss in SURMOUNT-1, the Phase 3 trial that earned its FDA approval

When initiating insulin therapy in type 2 diabetes, educating patients to selftitrate insulin doses on the basis of self-monitoring of blood glucose improves glycemic control (39)