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In the NEJM 2023 Phase 2 trial (Jastreboff et al.), the 12 mg weekly dose group achieved roughly 17.5 percent mean weight reduction by week 24, compared to roughly 1.6 percent in placebo
The key difference is in dosing, as tirzepatide escalation starts at 2.5mg rather than 0.25mg, which means much larger weekly doses and faster vial consumption
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Treating a B12 deficiency may boost energy and mood, reduce stress and fatigue, and decrease symptoms of multiple conditions
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