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But it also makes the molecule larger and structurally more complex than a single-hormone peptide
doi:10.3390/ijms222413662 Zhou L, Jang KY, Moon YJ, et al
Subjects lost up to 24% of their body weight in less than a year
So there was some type of maintained benefit in certain cases. Do weight loss drugs become less effective over time
Phase 2 data (published 2023) Phase 2 results published in the New England Journal of Medicine in 2023 provided the first substantial evidence for the mechanism, reporting dose-dependent body-weight reductions reaching approximately 24% at the highest doses, HbA1c improvements comparable to or exceeding tirzepatide, a safety profile dominated by gastrointestinal tolerability effects, and energy-expenditure increases documented by indirect calorimetry
This risk should be balanced against the benefits of patient comfort when selecting the optimal needle gauge for tirzepatide
