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Common pathways implicated in these conditions include dysregulated lipid metabolism, oxidative stress, and impaired energy metabolism, reflecting widespread dysfunction in fundamental biological processes

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Clonal hematopoiesis in human aging and disease

Srivastava KD, Bardina L, Sampson H, Li X-M

Most short-term studies (812 weeks) show mild or no side effects, but chronic use safety requires ongoing medical supervision

We next hypothesised that NADP oxidation during hypoxia may be due to NADPH consumption by the antioxidant machinery which is not matched by the rate of resupply due to limitations in flux through central metabolism