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The gradual approach serves multiple purposes
SAMe is biochemically produced through the folate-methionine cycle (see Figure 1), requiring many nutrients, including vitamin B12 and the healthy conversion of folic acid to 5-methyltetrahydrofolate (Guildford, n.d.)
Start with the lowest dose and increase gradually as tolerated
The lipotropic peptides guide covers these approaches in detail
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Clinical References Authoritative sources reviewed in preparing this clinical summary
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