The N-terminal Nle (norleucine) replaces the native Met-4, eliminating the oxidation-susceptible methionine
The medication continues to suppress appetite, and the health benefits, lower blood pressure, improved glucose control, reduced inflammation, persist as long as treatment continues
The medication is still preventing the full regain that would occur without it
This translates into a potential preservation of therapeutic options for later stages, a critical consideration for patients facing a progressive disease like PD
Try not to weigh yourself every day because this can be discouraging
The article notes that impairment can affect how both agents are handled and increases accumulation risk, and that the NAD salvage pathway involves liver enzymes