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Based on clinical trial data, tirzepatide generally produces lower rates of gastrointestinal side effects at weight loss doses despite causing greater weight loss
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Tirzepatide is contraindicated in patients with personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2, those with severe hypersensitivity to tirzepatide, and should be used cautiously in patients with history of pancreatitis or severe gastrointestinal disease
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Semaglutide's delay of gastric emptying could potentially alter the absorption profile of oral medications, including modified-release stimulant formulations
However, most research is required to confirm this effect
