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By way of example, Immune-Mediated Inflammatory disease, which includes Inflammatory Bowel Disease (IBD) and other varieties of gut dysbiosis, may lead to increased intestinal permeability, which allows the initiation and progression of osteoporosis

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The combination did not just add the individual effects together

These effects are hypothesized to stem from classical growth factor mechanisms, involving increased gene expression linked to cell growth, repair, and replacement, along with an elevation in cellular metabolism

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