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Immunoprecipitation studies revealed an increased association of FUS with XRCC1, LigIII, and PARP-1, but not with other base excision repair (BER) proteins in ALS patient-derived iPSC lines carrying FUS mutations (R521H and P525L)

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Khan et al., 2020)

If the issue was genuine non-response to GLP-1 agonism, the dual mechanism of tirzepatide might provide the additional GIP-receptor activation needed for results