The results revealed that the levels of pro-inflammatory cytokines IL-6, IL-12, and TNF- secreted by cells treated with NP4 were 1.45, 5, and 1.78 times higher than those secreted by cells treated with NP2, respectively, further confirming the activation of macrophages
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The authors also did not find any increase of degeneration of intervertebral discs adjacent to the fractures compared to the controls in this young cohort