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Adipose tissue is not merely a storage depot but an active endocrine organ that produces hormones, including oestrogen through the aromatisation of androgens
Overall, mean baseline age was 47.3 years, duration of obesity was 16.5 years, body weight was 115.8 kg, BMI was 40.4 kg/m 2 , WHtR was 0.71, HbA1c was 5.86%, FSG was 98.8 mg/dL and fasting insulin was 163.5 pmol/L
Realistic expectations are important
Several factors influence how semaglutide affects mood: Personal Brain Chemistry: Each person has a unique balance of neurotransmitters, which means semaglutide might affect one persons mood differently than anothers
The TRIUMPH-4 population (obesity + knee osteoarthritis) may have elevated baseline susceptibility due to existing nerve compression from joint inflammation
adults with diagnosed diabetes using a GLP-1 injectable in 2024
