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The molecular structure of GLP-1 peptides is large, hydrophilic, and electrically charged, which severely limits the ability of the molecule to pass the outer layer of the skin and enter the bloodstream, says Edwin Davila, DO, resident physician and obesity medicine expert for the National Academy of Sports Medicine

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The individual molecules are fine, but once they aggregate, they cannot function properly

GLP-1 receptor agonists can cause a range of potential side effects

Some do reach larger sizes.

Good hygiene, a fresh single-use needle and safe disposal remove most of that risk