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Together with folate, cobalamins are essential cofactors required for DNA synthesis in cells where chromosomal replication and division are occurringmost notably the bone marrow and myeloid cells

Their effectiveness improves with a healthy diet and exercise

Because it competes at the nicotinamide substrate site rather than the SAM cofactor site, it is also used as the substrate-competitive reference compound against which bisubstrate and covalent NNMT inhibitors are benchmarked

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Using restricted substances also threatens your malpractice coverage