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Most unmodified peptides share this limitation, which is why pharmaceutical GLP-1 receptor agonists like semaglutide required extensive chemical modification to enable oral delivery

The pH value was then recorded using the S220 SevenCompact TM pH/Ion meter (Mettler Toledo, Switzerland)

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If given IV, it must be injected slowly (often over at least 5 minutes or diluted in a larger volume bag and infused)

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