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In esophageal injury models, BPC-157 normalizes sphincter function by increasing pressure in both the lower esophageal sphincter (LES) and pyloric sphincter (PS) in animals with sphincter dysfunction, while in healthy animals the peptide demonstrates adaptive effects that maintain physiological sphincter tone
Additionally, as the primary location of iron storage, the liver maintains iron homeostasis by generating and secreting the principal regulator of iron hepcidin (Ganz, 2003)
[18] FDAs review also noted that pharmaceutical development for obesity was subsequently terminated and that detailed study design and results were not available in the peer-reviewed medical literature
106 , djt338 (2014)