Side Effects B12 has an excellent safety profile because it is water-soluble (excess is excreted in urine)
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Health experts recommended daily allowances (RDAs) for B12 intake recommendations vary by age, but the recommendations are the same regardless of your sex [1]: - 0 to 6 months 0.4 mcg - 7 to 12 months 0.5 mcg - 1 to 3 years 0.9 mcg - 4 to 8 years 1.2 mcg - 9 to 13 years 1.8 mcg - 14 years and older 2.4 mcg If youre pregnant, the National Institute of Health recommends you ingest at least 2.6 micrograms of B12 per day
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doi: 10.3389/fphar.2025.1602976 Received 30 March 2025 Revised 13 November 2025 Accepted 14 November 2025 Published 19 December 2025 Volume 16 - 2025 Edited by Bernd Rosenkranz, Fundisa African Academy of Medicines Development, South Africa Reviewed by Kacper Nijakowski, Poznan University of Medical Sciences, Poland Miriam Njoki Karinja, Science for Africa Foundation, Kenya Updates Copyright 2025 Mazur, Ndokaj, Salerno, Vallone, Ardan, Bietolini, Carrouel, Wilk, Sarig, Ottolenghi and Bourgeois
Lipo-Stat-Plus MIC with B6 and B12