Recombinant Human Nephroblastoma-overexpressed Gene Protein Homolog (Human NOV) _ C230451 Other growth factors Mature human BMP-2 has 100%

Mature human BMP-2 has 100% amino acid sequence identity with mouse and rat BMP-2

EIRNTEDLTE EWLREKLGFF H

corresponding to a specific activity of>1

and 98% homology with mouse/dog/horse

such as intestinal

Recombinant Human Nephroblastoma-overexpressed Gene Protein Homolog (Human NOV) _ C230451 Other growth factors Mature human BMP-2 has 100%NOV is a member of the CCN family of secreted, cysteine rich regulatory proteins. The full length NOV protein contains four structural domains that confer distinct, and sometimes opposing, biological activities. Elevated expression of NOV is associated with certain tumors, including Wilms tumor and most nephroblastomas. However, in other tumor types and certain cancer cell lines, increased tumorigenicity and proliferation is correlated with decreased