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REDEFINE 1, in adults with overweight or obesity without diabetes, reported 22.7% mean weight loss for the combination at 68 weeks on the on-treatment analysis, with 60% of combination participants reaching at least 20% loss and 23% reaching at least 30% (Aronne et al., 2025)
This observation suggests that radial axonal sorting, ensheathment, and potentially metabolic support are ancient glial functions that predate the evolutionary emergence of myelin in jawed vertebrates (Silva et al., 2022
As a person loses weight, their resting metabolic rate falls below what their new body weight would predict
Ablation of ferroptosis regulator glutathione peroxidase 4 in forebrain neurons promotes cognitive impairment and neurodegeneration
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