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This conservative approach reflects growing evidence that children and adolescents are more vulnerable to prolonged recovery and complications from repeated head trauma (9), even if they seem fine on the surface
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In the STEP 1 clinical trial (NEJM, 2021), participants on semaglutide 2.4 mg lost an average of 14.9% of body weight at 68 weeks (about 33.6 lbs from a 232 lb average baseline) vs 2.4% with placebo
Chronic inflammation is a major contributor to joint pain and discomfort (Sikora et al., 2021)
10.1016/j.actatropica.2018.01.007 18
(4) increased hepatic and renal urea cycle intermediates suggesting hypercatabolism and upregulation of the urea cycle independent of impaired renal clearance of nitrogenous waste
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