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IGF-1 LR3 acts more directly on tissue IGF-1 receptors and has a much longer activity window, but its human safety and efficacy data are essentially absent
The studied dosing starts low (about 2 mg weekly) and is increased roughly every four weeks to a target dose, with 12 mg being the highest dose in the main Phase 2 obesity trial
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Washington: National Academies Press (1994)
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