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Both groups maintained lifestyle interventions - 500-calorie daily deficit, 150 minutes weekly of physical activity

GLP1R activation might reduce cardiovascular morbidity indirectly through reductions in glycaemia, blood pressure, inflammation, postprandial lipaemia and body weight

Shifts the oxygen-hemoglobin dissociation curve to the left (increased affinity of hemoglobin for oxygen, reduced offloading of oxygen to tissues)

Systemic oxidative stress in asthma, COPD, and smokers

This change did not meaningfully change any findings and ensured consistency within the out-of-pocket maximum section of the Employee Cost Sharing section

* Percent Daily Reference Intakes (RI) are based on a 2,000 calorie diet