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Am J Gastroenterol 2008;103:2747-2756

Although supplementation with folate, vitamin B 6 , and vitamin B 12 successfully lowers homocysteine concentration in the blood, no significant effect on CVD risk has been demonstrated

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Within those categories, the clinical picture is clearer than the internet makes it seem

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However, as detailed above, cells that exhibit higher levels of mitochondrial activity are less sensitive to 5FU treatment, and those with compromised mitochondrial function are more sensitive, correlating with intrinsic resistance