Multiple physiological effects of GLP-1[1] Medications for diabetes comprise either GLP-1 receptor agonists, with short (one or two daily injections: Exenatide, Liraglutide, Lixisenatide) or long duration (one injection once weekly: extended-released Exenatide, Albiglutide, Dulaglutide, Taspoglutide)
The most common side effects are nausea, vomiting, diarrhea, constipation, and abdominal discomfort
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however, the exact mechanisms underpinning their utility in these cohorts are poorly understood
Papavramidis TS, Grosomanidis V, Papakostas P, Penna S, Kotzampassi K
Once rats achieved stable sucrose-motivated behavior on PR (at 9 weeks of age), AAV-expressing GFP (AAV-GFP) or the GLP-1R shRNA (AAV-GLP-1R-shRNA) was infused bilaterally into the LH (0.5 l per hemisphere during 5 min)