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114 However, another double-blind, placebo-controlled trial failed to show a significant benefit of magnesium, 330 mg as chloride per day, over placebo in neuropathic pain, although there was a significant improvement with regards to the frequency of pain paroxysms (attacks) and emotional impact in the magnesium group

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Further in vivo studies, taking into account the full biological context and environmental variables, are needed to confirm the benefits in the treatment of specific diseases 99,100

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Mol Neurobiol 57:47784789