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Diabetes Obes Metab 14:514 Dormandy JA, Charbonnel B, Eckland DJ, Erdmann E, Massi-Benedetti M, Moules IK, The PROactive Investigators (2005) Secondary prevention of macrovascular events in patients with type 2 diabetes in the PROactive study (PROspective pioglitAzone clinical trial in macro vascular events): a randomised controlled trial

Following a balanced plate model50% non-starchy veggies, 25% lean protein, and 25% carbohydratescan guide you with structure, without rigid counting

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Participants frequently report a reduction in blood sugar levels, leading to better glycemic control, which is especially significant for those managing diabetes

Essentially, this design emulated a randomised controlled trial, in which participants on a background therapy with one of the drug classes of interest (GLP-1 receptor agonists or SGLT-2 inhibitors) are randomised to either continue the background drug or add on the other drug of interest (SGLT-2 inhibitor or GLP-1 receptor agonist, respectively)