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Importantly, the cardiometabolic improvements seen during treatment such as healthier blood pressure, cholesterol, and glucose levels also reverted toward baseline after withdrawal
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There has been considerable interest in adapting semaglutide and other drugs in its class, which have a novel mechanism of action, targeting cellular receptors for a peptide called GLP-1
2009;4(5):e5393
The dose is then increased to 0.5 mg weekly, with further escalation to 1 mg and potentially 2 mg (after at least 4 weeks at each step) if additional glycaemic control is required
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