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The ADA doesnt recommend [archived link] compounded GLP-1 RAs due to uncertainty about their content, safety, quality, and effectiveness. The FDA has warned [archived link] about counterfeit and harmful GLP-1 RAs being sold online

Endotext [StatPearls]

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A combined effect that is bigger than just decreasing calories is thought to be at play when looking at the effects of activating the GLP-1 receptor.[ref] In overweight adults aged 45+, a 4-year-long study using semaglutide for weight loss also prevented HbA1c from rising over time, which was seen in the placebo arm

This is why tracking body composition is more valuable than tracking weight alone

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