Having a deep understanding of these different mechanisms allows for more sophisticated experimental design
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In rat and human tissue, high signals for GHSR1a mRNA are found expressed in several hypothalamic nuclei, the pituitary, and the dentate gyrus of the hippocampus, with additional yet reduced signals in CA2 and CA3 of the hippocampus, the substantia nigra, the ventral tegmental area, and the median raphe nuclei (Guan et al., 1997
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For example, some supplements may need to be taken with food, some may be administered daily, multiple times a day, or even weekly, she says