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It is known that amino acid conjugation of exogenous carboxylic acids occurs in a twostep process (Reilly et al., 2007)

Cancer cells in tumors with IDH1 or IDH2 mutations show oncogenic activity by converting glutamine-derived -KG to 2-hydroxyglutarate (2-HG), which competitively inhibits -KG-dependent histone and DNA modification enzymes 27

So if you're on a vegan or vegetarian diet where you're not eating foods from animals, you're at risk for B12 deficiency