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PGI 2 promotes vasodilation and inhibits platelet aggregation, whereas TXA 2 enhances vasoconstriction and platelet activation

Indeed GLP-1R agonists proved to be efficient for the treatment of type 2 diabetes mellitus 37 and studies indicate they could be used in other indications 26,43,44 such as obesity 45,46 , adverse cardiovascular events 25 , cognitive disorders 44 and non-alcoholic steatohepatitis (NASH) 47

Liraglutide shows dose-dependent nausea ratesVictoza (for diabetes) has rates around 10-17% depending on dose, while Saxenda (3.0 mg for weight management) has significantly higher nausea rates of approximately 39% according to its SmPC

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The glucagon receptor component drives metabolic improvements that dual agonists do not achieve as effectively

taking NAD+ by mouth is not effective since NAD+ is not absorbed intact