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If levels don't respond to standard supplementation, investigate possible MTHFR polymorphisms, malabsorption conditions like celiac or Crohn's disease, or potential medication interactions

& Medzhitov, R

doi: 10.1007/s10620-015-3632-x 129 MaoFWuYTangXKangJZhangBYanYet al

Based on the findings and limitations of this review, future research should focus on optimizing study design by strictly implementing randomization, controlled conditions, and blinding to improve the methodological quality of animal studies, while standardizing the reporting of animal numbers and data completeness

Gronke, L