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For patients with hypertension, this may translate into reduced cardiovascular risk, though antihypertensive medications should not be discontinued without medical supervision

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Expected Weight Loss: In the head-to-head SURMOUNT-5 trial published in The New England Journal of Medicine , tirzepatide was shown to be superior to semaglutide for reduction in body weight and waist circumference at 72 weeks among adults with obesity (without diabetes)

10.3389/fphar.2020.589114 Front