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Initially developed for managing type 2 diabetes, theyve also been shown to lead to significant weight loss, which has led to their off-label and approved use in people without diabetes

The paraventricular nucleus integrates these signals and coordinates downstream responses including reduced food intake

This structure acknowledges that "there's more to weight loss than GLP-1s" and addresses the root cause

Lancet 392(10160):21802193

- Oral semaglutide (only FDA approved for diabetes treatment) and injectable liraglutide, (FDA approved for obesity treatment as Saxenda,) lead to relatively modest amount of weight loss

The broader context of how weight management fits into hormonal and metabolic health particularly for men with low testosterone alongside obesity is covered in the weight loss overview