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Its encoded protein, circINSIG1-121, recruits the CUL5-ASB6 E3 ligase complex to promote K48-linked ubiquitination of INSIG1a key regulator of cholesterol metabolismat lysine residues 156 and 158, thereby inducing cholesterol synthesis and subsequently facilitating CRC cell proliferation and metastasis (71)
Peroxisomes contain a wide range of flavoproteins or oxidoreductases enzymes namely Acyl-CoA oxidas, polyamine, oxidase D-aspartate oxidase, D-amino acid oxidase, L-pipecolic acid oxidase, L--hydroxyacid oxidase etc
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