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Chromatographic separation was undertaken using an Acquity HSS T3 UPLC (ultra-performance LC

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They naturally fluctuate throughout a 24-hour cycle, often dipping when we are most exposed to environmental stressors or when our internal repair mechanisms are working overtime

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Here we aimed to pharmacologically interfere with TBC1D15-mediated Rab7 inactivation to upregulate Rab7 activity and reduce cholesterol accumulation in NPC1 mutant models

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