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Amylin and calcitonin receptor signalling mechanisms
Weaken one side and the other has to work against a rising tide: low glutathione means more oxidative damage for NAD+-dependent repair to clear, and declining NAD+ means less capacity to power that repair in the first place
Novo Nordisk developed it as a long-acting version of the naturally occurring hormone, engineered with specific amino acid substitutions that extend its duration of action from minutes to days
Formation of intermolecular disulfide bonds mediates association of the two subunits (Seelig et al., 1984
Our data indicated that the TmGst1 and TmGst3 were transcriptionally responsive to CDNB in a phase-specific manner
We sought to determine whether the maintained adaptive level was sufficient to prevent CS induced GSH depletion upon repeated CS exposures
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