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In a more complex murine CRC model, we used orthotopic endoscopy-guided submucosal injection 24,25,26 of 4-hydroxytamoxifen to drive allelic recombination in AKP mice and promote tumour formation

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Notably, Bmal1 KO adipocytes had reduced expression of Pparg , Tcf712 (a regulator of lipid and glucose metabolism 32 ) and several genes involved in lipid metabolism and adipogenesis (Fig

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