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Ongoing signaling stops once you stop applying, which is why most users treat GHK-Cu as long-term maintenance

This makes dosing errors more likely than with commercially manufactured drugs

Shorter cycles (4-6 weeks) are sometimes used for cutting phases or competition preparation, while longer cycles (12-16 weeks) suit individuals with significant fat loss goals

Additionally, some research suggests chronic GLP-1 agonist use may reduce gastric acid secretion over time, though this finding remains controversial

doi:10.1038/nrendo.2013.78

This is common with many metabolic peptides and supplementsyour body develops tolerance, and the initial benefits diminish