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Eksp Klin Farmakol 2011;74(11):17-23
Authors concluded that, in the process of prostate carcinogenesis, activating histone modifications on GSTP1 are lost and subsequently DNA becomes methylated and inaccessible resulting in transcriptional silencing thus demonstrating interplay between histone reprogramming and promoter region methylation (Okino et al., 2007)
Samples should therefore be collected, cooled, deproteinized, and stabilized with a validated method as quickly as possible
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